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April 02, 2026 Dear Reader, Vaccinology has always been a wager on our ability to outthink evolution. With Lyme borreliosis, the odds have long favored a shape-shifting spirochete and its Ixodes vector. New phase 3 data from the Pfizer/Valneva OspA-based vaccine suggest we may be closing that gap: a multivalent construct that matches the Borrelia ecology in North America and Europe, in an appropriately sized trial for relevant endpoints against the realities of vector-borne diseases. The results read, in part, as a quiet rebuttal to the legacy of LYMErix: the science was not the limiting factor.This issue stays briefly with Lyme disease in our infographic. We also examine hand, foot and mouth disease in Vietnam, where a fivefold early-year surge highlights the limits of hygiene in the absence of vaccination. The TBE snapshot from the Åland Islands considers early signals following the rollout of a general vaccination program. In the news: World Immunization Week, Strategic Advisory Group of Experts on Immunization, polio’s persistent “emergency” status, and shifting U.S. schedule politics—all reinforcing a familiar conclusion: vaccines work; vaccination remains contested. Enjoy the reading! With best wishes for your continued health, and receive the vaccine doses you need. Warm regards, Editor-in-Chief, Global Health Press |
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